N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Base Information

Chemical Name:N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide
CAS No.:1613228-49-1
Molecular Formula:C₂₈H₂₂ClF₃N₆O₃
Molecular Weight:582.969
Hs Code.:

Synonyms:N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

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Chemical Property of N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

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Technology Process of N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

There total 8 articles about N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(2-((3-aminophenyl)amino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide: 1431727-20-6
N-(2-((3-aminophenyl)amino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

: 79-04-9
chloroacetyl chloride

: 1613228-49-1
N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1021/jm4017762

Reference yield:

: 454-92-2
3-(trifluoromethyl)benzoic acid

: 1613228-49-1
N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 1 h / Reflux

2: dichloromethane / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 1 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4017762

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 1613228-49-1
N-(2-(3-(2-chloroacetamido)phenylamino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4017762