N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Base Information

• Chemical Name: N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide
• CAS No.: 142688-84-4
• Molecular Formula: C₂₇H₅₁N₃O₅
• Molecular Weight: 497.719

Synonyms:N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Chemical Property of N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

There total 1 articles about N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-(3-Aminopropyl)morpholine (123-00-2) + (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one (124032-36-6) → N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide (142688-84-4)

Guidance literature:

at 60 ℃; for 96h;

DOI:10.1021/jm00045a003

Reference yield: 92.0%

N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide (142688-84-4) → N-(3-(4-oxido-4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide (142687-65-8)

Guidance literature:

With dihydrogen peroxide; In methanol; at 50 ℃; for 48h;

DOI:10.1021/jm00045a003

Reference yield:

N-(3-(4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide (142688-84-4) → (2S,4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid (3-morpholin-4-yl-propyl)-amide (138679-12-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1021/jm00045a003

upstream raw materials:

4-(3-Aminopropyl)morpholine

(3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one

Downstream raw materials:

(2S,4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid (3-morpholin-4-yl-propyl)-amide

N-(3-(4-oxido-4-morpholino)propyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

(2S,4S,5S)-5-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethylamino]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid (3-morpholin-4-yl-propyl)-amide

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