Technology Process of 5-Bromo-2,6-dimethoxy-3-pivaloylbenzoic Acid
There total 7 articles about 5-Bromo-2,6-dimethoxy-3-pivaloylbenzoic Acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
acetic acid; zinc;
In
tetrahydrofuran;
for 3.5h;
ice bath;
DOI:10.1021/jo00065a015
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) SOCl2, DMF / 1) toluene, 2) CH2Cl2, overnight
2: trifluoroacetic anhydride / 1) 40 deg C, 8 h, 2) rt, 16 h
3: m-chloroperbenzoic acid, p-TsOH / CHCl3 / 24 h / Ambient temperature
4: aq. HCl / acetone / 6 h / 60 °C
5: 89 percent / CHCl3; trifluoroacetic acid / 16 h / 60 °C
6: 90 percent / Br2 / CHCl3; trifluoroacetic acid / 4.5 h / Ambient temperature
7: 63 percent / Zn, aq. HOAc / tetrahydrofuran / 3.5 h / ice bath
With
hydrogenchloride; thionyl chloride; bromine; toluene-4-sulfonic acid; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; zinc;
In
tetrahydrofuran; chloroform; acetone; trifluoroacetic acid;
DOI:10.1021/jo00065a015
- Guidance literature:
-
Multi-step reaction with 6 steps
1: trifluoroacetic anhydride / 1) 40 deg C, 8 h, 2) rt, 16 h
2: m-chloroperbenzoic acid, p-TsOH / CHCl3 / 24 h / Ambient temperature
3: aq. HCl / acetone / 6 h / 60 °C
4: 89 percent / CHCl3; trifluoroacetic acid / 16 h / 60 °C
5: 90 percent / Br2 / CHCl3; trifluoroacetic acid / 4.5 h / Ambient temperature
6: 63 percent / Zn, aq. HOAc / tetrahydrofuran / 3.5 h / ice bath
With
hydrogenchloride; bromine; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; zinc;
In
tetrahydrofuran; chloroform; acetone; trifluoroacetic acid;
DOI:10.1021/jo00065a015
