2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate

Base Information

• Chemical Name: 2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate
• CAS No.: 148460-81-5
• Molecular Formula: C₁₁H₁₁Cl₃O₄
• Molecular Weight: 313.565
• Mol file: 148460-81-5.mol

Synonyms:

Chemical Property of 2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate

There total 1 articles about 2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1,1-trichloroethanol (115-20-8) + 2-6-dimethoxybenzoic acid (1466-76-8) → 2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate (148460-81-5)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1) toluene, 2) CH₂Cl₂, overnight;

DOI:10.1021/jo00065a015

Reference yield:

2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate (148460-81-5) → (S)-2,6-Dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>-3-pivaloylbenzamide (148460-96-2)

Guidance literature:

Multi-step reaction with 7 steps

1: trifluoroacetic anhydride / 1) 40 deg C, 8 h, 2) rt, 16 h

2: m-chloroperbenzoic acid, p-TsOH / CHCl₃ / 24 h / Ambient temperature

3: aq. HCl / acetone / 6 h / 60 °C

4: 89 percent / CHCl₃; trifluoroacetic acid / 16 h / 60 °C

5: 67 percent / Zn, aq. HOAc / tetrahydrofuran / 3.5 h / ice bath

6: SOCl₂, DMF / toluene / 1.5 h / 60 °C

7: CH₂Cl₂

With hydrogenchloride; thionyl chloride; toluene-4-sulfonic acid; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; zinc; In tetrahydrofuran; dichloromethane; chloroform; acetone; toluene; trifluoroacetic acid;

DOI:10.1021/jo00065a015

Reference yield:

2,2,2-Trichloroethyl 2,6-Dimethoxybenzoate (148460-81-5) → FLA 873 (101460-36-0)

Guidance literature:

Multi-step reaction with 9 steps

1: trifluoroacetic anhydride / 1) 40 deg C, 8 h, 2) rt, 16 h

2: m-chloroperbenzoic acid, p-TsOH / CHCl₃ / 24 h / Ambient temperature

3: aq. HCl / acetone / 6 h / 60 °C

4: 89 percent / CHCl₃; trifluoroacetic acid / 16 h / 60 °C

5: 90 percent / Br₂ / CHCl₃; trifluoroacetic acid / 4.5 h / Ambient temperature

6: 63 percent / Zn, aq. HOAc / tetrahydrofuran / 3.5 h / ice bath

7: SOCl₂, DMF / toluene / 1.5 h / 60 °C

8: CH₂Cl₂

9: 88 percent / aq. HCl / 4 h / 80 °C

With hydrogenchloride; thionyl chloride; bromine; toluene-4-sulfonic acid; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; zinc; In tetrahydrofuran; dichloromethane; chloroform; acetone; toluene; trifluoroacetic acid;

DOI:10.1021/jo00065a015

upstream raw materials:

1,1,1-trichloroethanol

2-6-dimethoxybenzoic acid

Downstream raw materials:

2,2,2-Trichloroethyl 3-Acetyl-2,6-dimethoxybenzoate

FLA 873

2,6-Dimethoxy-3-pivaloylbenzoic Acid

2,2,2-Trichloroethyl 2,6-Dimethoxy-3-hydroxybenzoate

Refernces