6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

Base Information

Chemical Name:6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid
CAS No.:204501-99-5
Molecular Formula:C₂₃H₃₆N₂O₆
Molecular Weight:436.549
Hs Code.:

6-<i>tert</i>-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

Synonyms:6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

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Chemical Property of 6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

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Technology Process of 6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

There total 1 articles about 6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2418-95-3
(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 204501-99-5
6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

Guidance literature:: With sodium cyanoborohydride; In ethanol; water; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2006.06.004

Reference yield: 74.0%

: 204501-99-5
6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

: 4299-70-1
L-tryptophan methyl ester

: 910301-25-6
2-{5-tert-butoxycarbonylamino-1-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethylcarbamoyl]-pentylamino}-4-phenyl-butyric acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1016/j.bmcl.2006.06.004

Reference yield:

: 204501-99-5
6-tert-butoxycarbonylamino-2-(1-ethoxycarbonyl-3-phenyl-propylamino)-hexanoic acid

: 2-{(S)-5-Amino-1-[(S)-2-(1H-indol-3-yl)-1-methoxycarbonyl-ethylcarbamoyl]-pentylamino}-4-phenyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / EDC*HCl; HOBt; diisopropylethylamine / dimethylformamide / 72 h / 20 °C

2: aq. HCl / ethyl acetate / 24 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.004