2418-95-3

Basic information

• Product Name: Ne-Boc-L-lysine
• Synonyms: epsilon-tert-butyloxycarbonyl-lysine;L-LYSINE(BOC);LYSINE(BOC)-OH;LYS(BOC);H-LYS(BOC)-OH;H-L-LYS(BOC)-OH;N-ALPHA-T-BOC-L-LYS;N-EPSILON-(TERT-BUTOXYCARBONYL)-L-LYSINE
• CAS NO: 2418-95-3
• Molecular Formula: C₁₁H₂₂N₂O₄
• Molecular Weight: 246.3
• Product Categories: Amino Acids;Lysine [Lys, K];Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series
• Mol File: 2418-95-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 250 °C (dec.)(lit.)
• Boiling Point: 389.3°C (rough estimate)
• Flash Point: 203.5 °C
• Appearance: white crystalline powder
• Density: 1.1313 (rough estimate)
• Refractive Index: 18 ° (C=1, AcOH)
• Storage Temp.: 2-8°C
• PKA: 2.53±0.24(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 2417626
• CAS DataBase Reference: Ne-Boc-L-lysine(CAS DataBase Reference)
• NIST Chemistry Reference: Ne-Boc-L-lysine(2418-95-3)
• EPA Substance Registry System: Ne-Boc-L-lysine(2418-95-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 2418-95-3(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

It is used as therapy to treat recurrent herpes simplex infections.

InChI:InChI=1/C11H22N2O4/c1-11(2,3)17-10(16)8(13)6-4-5-7(12)9(14)15/h7-8H,4-6,12-13H2,1-3H3,(H,14,15)/t7-,8?/m0/s1

Upstream product

• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 56-87-1 L-lysine 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 27097-41-2 N-ε-tert-butyloxycarbonyl-L-lysine N-carboxyanhydride 
• 2389-60-8 Z-Lys(Boc)-OH 
• 109794-81-2 Z-L-Glu(OtBu)-L-Lys(Boc)-OH 
• 86060-98-2 Fmoc-L-Lys(Boc)-OPfp 
• 75141-52-5 Z-Arg(δ,ω-Z2)-Lys(BOC)-OH 
• 138296-23-8 N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^ε-(tert-butyloxycarbonyl)-lysine 
• 85382-01-0 Z-L-Ser(tBu)-L-Lys(Boc)OH 
• 85313-52-6 Nε-Boc-Nα-t-Bumeoc-L-Lys-OH 
• 80220-23-1 Z-Ile-Arg(Mds)-Pro-Lys(Boc)-OH 
• 3236-13-3 Z-Ser-Lys(Boc)-OH 
• 3105-95-1 pipecolinic acid 
• 98210-36-7 N^α-Asul-N^ε-Boc-Lys 
• 23500-04-1 N²-acetyl-N⁶-(tert-butyloxycarbonyl)-L-lysine 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 

Relevant articles and documents

Thermal cleavage of the Fmoc protection group

The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.

Dual linker with a reference cleavage site for information rich analysis of polymer-supported transformations

Two dual linker systems with specific reference cleavage sites were designed and synthesized to accelerate and simplify development and optimization of reaction conditions for solid-phase synthesis. The dual linker allows simple evaluation of cleavage rate of polymer-supported compounds from the linker and, at the same time, ensures that all resin-bound components are cleaved from the solid support. The dual linker 4 was assembled from two Wang linkers connected by a three carbon spacer. The linker 9 was synthesized using the PAL and HMPB linkers.