(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

Base Information

Chemical Name:(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one
CAS No.:88981-69-5
Molecular Formula:C₃₄H₃₂N₂O₄S₂
Molecular Weight:596.771
Hs Code.:

Synonyms:(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

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Chemical Property of (+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

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Technology Process of (+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

There total 14 articles about (+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 106-95-6
allyl bromide

: 88981-67-3
(10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

: 88981-69-5
(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

Guidance literature:: With potassium hexamethylsilazane; at 0 ℃;
DOI:10.1039/c39850000184

Reference yield:

: 88981-65-1
(R_S)-p-tolylsulfinylacetic acid

: 88981-69-5
(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodi-imide metho-p-toluene sulphonate

2: 69 percent / trifluoroacetic anhydride / CH₂Cl₂; chlorobenzene / 130 °C

3: 81 percent / KN(SiMe₃)2 / 0 °C

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; potassium hexamethylsilazane; trifluoroacetic anhydride; In dichloromethane; chlorobenzene;
DOI:10.1039/c39850000184

Reference yield:

: 84960-67-8
cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)-sulfonyl>-1H-pyrido<3,2-c>carbazole

: 88981-69-5
(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(prop-2-en-1-yl)-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodi-imide metho-p-toluene sulphonate

2: 69 percent / trifluoroacetic anhydride / CH₂Cl₂; chlorobenzene / 130 °C

3: 81 percent / KN(SiMe₃)2 / 0 °C

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; potassium hexamethylsilazane; trifluoroacetic anhydride; In dichloromethane; chlorobenzene;
DOI:10.1039/c39850000184