(3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

Base Information

Chemical Name:(3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine
CAS No.:474103-80-5
Molecular Formula:C₂₇H₃₄O₆
Molecular Weight:454.563
Hs Code.:

Synonyms:(3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

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Chemical Property of (3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

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Technology Process of (3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

There total 8 articles about (3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100-39-0
benzyl bromide

: 474103-78-1
(3aR,4S,5S,5aR,9aR,9bS)-2,2,8,8-Tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine-4,5-diol

: 474103-80-5
(3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

Guidance literature:: With sodium hydride;
DOI:10.1016/S0040-4039(02)01121-8

Reference yield:

: 474103-76-9
(3aR,4S,5aS,9aR,9bS)-2,2,8,8-Tetramethyl-5-methylene-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-ol

: 474103-80-5
(3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 3 steps

1: O₃ / methanol; CH₂Cl₂ / -78 °C

2: 205 mg / NaBH₄; CeCl₃*H₂O / methanol / 0 - 20 °C

3: 72 percent / NaH; Bu₄NI / tetrahydrofuran / 3 h

With sodium tetrahydroborate; cerium(III) chloride; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.200300339

Reference yield:

: 474103-74-7
Carbonic acid ethyl ester (3aR,4S,5aS,9aR,9bS)-2,2,8,8-tetramethyl-5-methylene-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-yl ester

: 474103-80-5
(3aR,4S,5S,5aR,9aR,9bS)-4,5-Bis-benzyloxy-2,2,8,8-tetramethyl-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / K₂CO₃ / methanol

2: O₃ / methanol; CH₂Cl₂ / -78 °C

3: 205 mg / NaBH₄; CeCl₃*H₂O / methanol / 0 - 20 °C

4: 72 percent / NaH; Bu₄NI / tetrahydrofuran / 3 h

With sodium tetrahydroborate; cerium(III) chloride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; ozone; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.200300339