Technology Process of (2R)-2-amino-N-benzyl-3-methoxypropanamide (2R,3R)-tartrate
There total 3 articles about (2R)-2-amino-N-benzyl-3-methoxypropanamide (2R,3R)-tartrate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-N-benzyl-2-(dibenzylamino)-3-methoxypropanamide;
With
5%-palladium/activated carbon; hydrogen; acetic acid;
In
isopropyl alcohol; toluene;
at 40 - 45 ℃;
under 2068.65 - 5068.18 Torr;
L-Tartaric acid;
In
isopropyl alcohol; toluene;
at 60 - 65 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / toluene / 24 h / 0 - 10 °C
2.1: hydrogen; acetic acid; 5%-palladium/activated carbon / toluene; isopropyl alcohol / 40 - 45 °C / 2068.65 - 5068.18 Torr
2.2: 60 - 65 °C
With
5%-palladium/activated carbon; tetrabutylammomium bromide; hydrogen; acetic acid; sodium hydroxide;
In
isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 0 - 10 °C
2.1: tetrabutylammomium bromide; sodium hydroxide / toluene / 24 h / 0 - 10 °C
3.1: hydrogen; acetic acid; 5%-palladium/activated carbon / toluene; isopropyl alcohol / 40 - 45 °C / 2068.65 - 5068.18 Torr
3.2: 60 - 65 °C
With
5%-palladium/activated carbon; tetrabutylammomium bromide; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
dichloromethane; isopropyl alcohol; toluene;
