3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester
CAS No.:932019-47-1
Molecular Formula:C₂₆H₃₁NO₇
Molecular Weight:469.535
Hs Code.:

3-<i>tert</i>-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

Synonyms:3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

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Chemical Property of 3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

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Technology Process of 3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

There total 1 articles about 3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 70-11-1
α-bromoacetophenone

: 218943-30-7
(3S)-3-tert-butoxycarbonylamino-5-benzyloxycarbonylpentanoic acid

: 932019-47-1
3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h;
DOI:10.1021/ol0629622

Reference yield:

: 932019-47-1
3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

: 3-amino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1021/ol0629622

Reference yield:

: 932019-47-1
3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2-oxo-2-phenyl-ethyl) ester

: 932019-54-0
3-(5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-hexanedioic acid 6-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / dioxane

2: 96 percent / N,N-diisopropylethylamine; HATU / dimethylformamide / 21 h / 0 - 20 °C

3: 68 percent / acetic acid; zinc / dimethylformamide; H₂O / 3 h / 20 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol0629622