2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester

Base Information

• Chemical Name: 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester
• CAS No.: 881911-37-1
• Molecular Formula: C₄₃H₄₁NO₇
• Molecular Weight: 683.801
• Mol file: 881911-37-1.mol

Synonyms:2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester

Chemical Property of 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester

There total 7 articles about 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzoic acid + tert-Butyl 2,2,2-trichloroacetimidate (98946-18-0) → 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester (881911-37-1)

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm050910x DOI:10.1039/b515432d

Reference yield:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-formyl-4-hydroxy-phenyl)-propionic acid → 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester (881911-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 758 mg / K₂CO₃; n-Bu₄NI / dimethylformamide / 20 °C

2: Ag₂O; aq. NaOH / 24 h

3: 150 mg / BF₃*Et₂O / tetrahydrofuran / 16 h / 20 °C

With sodium hydroxide; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; potassium carbonate; silver(l) oxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/b515432d

Reference yield:

3-(4-benzyloxy-3-formylphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid benzyl ester (881911-36-0) → 2-benzyloxy-5-[2-benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]benzoic acid tert-butyl ester (881911-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Ag₂O; aq. NaOH / 24 h

2: 150 mg / BF₃*Et₂O / tetrahydrofuran / 16 h / 20 °C

With sodium hydroxide; boron trifluoride diethyl etherate; silver(l) oxide; In tetrahydrofuran;

DOI:10.1039/b515432d

upstream raw materials:

tert-Butyl 2,2,2-trichloroacetimidate

3-(4-benzyloxy-3-formylphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid benzyl ester

Boc-Tyr-OH

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide