1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Base Information

Chemical Name:1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate
CAS No.:1055305-18-4
Molecular Formula:C₄H₄O₄*C₁₇H₁₅ClFN₃O₂S
Molecular Weight:495.916
Hs Code.:

Synonyms:1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

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Chemical Property of 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

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Technology Process of 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

There total 9 articles about 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1055306-81-4
tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1055305-18-4
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Guidance literature:: tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate; With hydrogenchloride; ethanol; In ethyl acetate; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

(2E)-but-2-enedioic acid; In ethanol; ethyl acetate; at 20 ℃; for 0.25h;

Reference yield:

: 1055306-70-1
tert-butyl [4-(2-chloropyridin-3-yl)-3,3-difluoro-2-methylene-4-oxobutyl]carbamate

: 1055305-18-4
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

2.2: 0.5 h / 0 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 0.5 h / 0 °C

4.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

4.2: 14 h / 0 °C / Heating / reflux

4.3: 1 h / 20 °C

5.1: hydrogenchloride; ethanol / ethyl acetate / 4 h / 20 °C

5.3: 0.25 h / 20 °C

With hydrogenchloride; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; acetic acid; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 2-chloro-3-(4,4-difluoro-3-methylene-3,4-dihydro-2H-pyrrol-5-yl)pyridine

: 1055305-18-4
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

1.2: 0.5 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

3.2: 14 h / 0 °C / Heating / reflux

3.3: 1 h / 20 °C

4.1: hydrogenchloride; ethanol / ethyl acetate / 4 h / 20 °C

4.3: 0.25 h / 20 °C

With hydrogenchloride; ethanol; carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; In tetrahydrofuran; ethyl acetate;