tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Base Information

Chemical Name:tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate
CAS No.:1055306-81-4
Molecular Formula:C₂₂H₂₃ClFN₃O₄S
Molecular Weight:479.96
Hs Code.:

Synonyms:tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

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Chemical Property of tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

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Technology Process of tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

There total 6 articles about tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1055306-79-0
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

: 24424-99-5
di-tert-butyl dicarbonate

: 1055306-81-4
tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Guidance literature:: 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine; With carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran; at 0 ℃; for 1h;

With triethylamine; In tetrahydrofuran; at 0 ℃; for 14h; Heating / reflux;

di-tert-butyl dicarbonate; In ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 2-chloro-3-(4,4-difluoro-3-methylene-3,4-dihydro-2H-pyrrol-5-yl)pyridine

: 1055306-81-4
tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

1.2: 0.5 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

3.2: 14 h / 0 °C / Heating / reflux

3.3: 1 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; In tetrahydrofuran;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055306-81-4
tert-butyl {[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

3.2: 0.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

4.2: 0.5 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

5.2: 14 h / 0 °C / Heating / reflux

5.3: 1 h / 20 °C

With hydrogenchloride; n-butyllithium; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; acetic acid; diisopropylamine; In tetrahydrofuran; hexane;