4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

Base Information

Chemical Name:4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide
CAS No.:1047671-57-7
Molecular Formula:C₁₈H₂₁ClN₃O₂S*I
Molecular Weight:505.807
Hs Code.:

Synonyms:4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

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Chemical Property of 4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

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Technology Process of 4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

There total 7 articles about 4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1047673-45-9
1-azabicyclo[2.2.2]oct-4-yl [5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamate hydrochloride

: 74-88-4
methyl iodide

: 1047671-57-7
4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

Guidance literature:: 1-azabicyclo[2.2.2]oct-4-yl [5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamate hydrochloride; With sodium hydroxide; In water; for 0.25h;

methyl iodide; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: C₁₀H₅ClN₄OS

: 1047671-57-7
4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 1 h / 90 °C

2.1: toluene; N,N-dimethyl-formamide / 2 h / Reflux

3.1: sodium hydroxide / water / 0.25 h

3.2: 1 h / 20 °C

With sodium hydroxide; In water; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: C₁₀H₅ClN₂OS

: 1047671-57-7
4-({[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamoyl}oxy)-1-methyl-1-azoniabicyclo[2.2.2]octane iodide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene; N,N-dimethyl-formamide / 2 h / Reflux

2.1: sodium hydroxide / water / 0.25 h

2.2: 1 h / 20 °C

With sodium hydroxide; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2014.04.031