7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

Base Information

Chemical Name:7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole
CAS No.:1307813-40-6
Molecular Formula:C₂₉H₂₈F₃N₃O₆
Molecular Weight:571.553
Hs Code.:

Synonyms:7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

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Chemical Property of 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

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Technology Process of 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

There total 14 articles about 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1307812-23-2
N-hydroxy-3-phenyl-4-(trifluoromethyl)isoxazole-5-carbimidoyl chloride

: 1307813-39-3
4-(7-(2,2-dimethyl-1,3-dioxolan-4-yl)-2H-chromen-4-yl)-morpholine

: 1307813-40-6
7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307813-40-6
7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 20 °C

3: Dess-Martin periodane / dichloromethane / 3.7 h / 0 - 20 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 - 80 °C

5: N-chloro-succinimide / N,N-dimethyl-formamide / 0.87 h / 20 °C

6: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; triethylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 76240-27-2
7-hydroxy-2,3-dihydro-4H-chromen-4-one

: 1307813-40-6
7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 2.58 h / 0 - 20 °C

2: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

4: (R)-10-camphorsulfonic acid / acetone / 20 °C

5: titanium tetrachloride / toluene / 0 - 20 °C

6: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

With osmium(VIII) oxide; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; acetone; toluene;