(9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol

Base Information

• Chemical Name: (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol
• CAS No.: 1307813-43-9
• Molecular Formula: C₂₅H₂₂F₃N₃O₅
• Molecular Weight: 501.462
• Mol file: 1307813-43-9.mol

Synonyms:(9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol

Chemical Property of (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol

There total 18 articles about (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol (1307813-43-9)

Guidance literature:

Multi-step reaction with 9 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 20 °C

3: Dess-Martin periodane / dichloromethane / 3.7 h / 0 - 20 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 - 80 °C

5: N-chloro-succinimide / N,N-dimethyl-formamide / 0.87 h / 20 °C

6: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

7: trifluoroacetic acid / 1 h / 20 °C

8: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

9: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazole-7-carbaldehyde (1307813-42-8) → (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol (1307813-43-9)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 0.5h;

Reference yield:

7-hydroxy-2,3-dihydro-4H-chromen-4-one (76240-27-2) → (9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol (1307813-43-9)

Guidance literature:

Multi-step reaction with 9 steps

1: pyridine / 2.58 h / 0 - 20 °C

2: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

4: (R)-10-camphorsulfonic acid / acetone / 20 °C

5: titanium tetrachloride / toluene / 0 - 20 °C

6: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

7: trifluoroacetic acid / 1 h / 20 °C

8: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

9: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; acetone; toluene;

upstream raw materials:

7-hydroxy-2,3-dihydro-4H-chromen-4-one

4-oxochroman-7-yl trifluoromethanesulfonate

recorcinol

phenylhydroxamoyl chloride

Downstream raw materials:

1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)-azetidine-3-carboxylic acid

(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazole-7-carbaldehyde

tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate