{4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

Base Information

Chemical Name:{4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester
CAS No.:634197-93-6
Molecular Formula:C₂₄H₂₄N₆O₅
Molecular Weight:476.492
Hs Code.:

Synonyms:{4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

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Chemical Property of {4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

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Technology Process of {4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

There total 10 articles about {4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 645-08-9,74309-78-7
Isovanillic acid

: 634197-93-6
{4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 91 percent / K₂CO₃ / dimethylformamide / 20 °C

2: 100 percent / HNO₃; Ac₂O / 3 h / 20 °C

3: 73 percent / Fe; FeCl₃; AcOH / ethanol; H₂O / 4 h / 80 °C

4: 100 percent / 5 h / 190 °C

5: 89 percent / POCl₃ / 3 h / Heating

6: 88 percent / Et₃N / tetrahydrofuran; CHCl₃ / 20 °C

7: 79 percent / H₂ / Pd/C / ethanol; H₂O / 5 h / 50 °C

8: 77 percent / K₂CO₃ / dimethylformamide / 20 °C

9: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

10: Et₃N / dimethylformamide / 20 °C

With hydrogen; nitric acid; acetic anhydride; iron(III) chloride; iron; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v

Reference yield:

: 286371-65-1
6-(benzyloxy)-4-chloro-7-methoxyquinazoline

: 634197-93-6
{4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / Et₃N / tetrahydrofuran; CHCl₃ / 20 °C

2: 79 percent / H₂ / Pd/C / ethanol; H₂O / 5 h / 50 °C

3: 77 percent / K₂CO₃ / dimethylformamide / 20 °C

4: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

5: Et₃N / dimethylformamide / 20 °C

With hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v

Reference yield:

: 286371-64-0
6-(benzyloxy)-7-methoxyquinazolin-4(3H)-one

: 634197-93-6
{4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / POCl₃ / 3 h / Heating

2: 88 percent / Et₃N / tetrahydrofuran; CHCl₃ / 20 °C

3: 79 percent / H₂ / Pd/C / ethanol; H₂O / 5 h / 50 °C

4: 77 percent / K₂CO₃ / dimethylformamide / 20 °C

5: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

6: Et₃N / dimethylformamide / 20 °C

With hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v