N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

Base Information

Chemical Name:N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea
CAS No.:117023-86-6
Molecular Formula:C₂₉H₃₃F₂N₃O₃
Molecular Weight:509.596
Hs Code.:

Synonyms:N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

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Technology Process of N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

There total 8 articles about N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 624-83-9
methyl isocyanate

: 117023-80-0
1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

: 117023-86-6
N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

Guidance literature:: In benzene; for 1h;
DOI:10.1021/jm00121a022

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 117023-86-6
N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / acetone / 24 h / Heating

2: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

3: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

4: 31 percent / benzene / 1 h

With hydrogen; sodium carbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; acetone; butan-1-ol; benzene;
DOI:10.1021/jm00121a022

Reference yield:

: 79096-54-1
1-(3-Chloropropoxy)-4-nitrobenzene

: 117023-86-6
N-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]-N'-methylurea

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

2: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

3: 31 percent / benzene / 1 h

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; butan-1-ol; benzene;
DOI:10.1021/jm00121a022