Thiomethylpromazine

Base Information

Chemical Name:Thiomethylpromazine
CAS No.:1039-59-4
Molecular Formula:C₁₈H₂₂N₂S₂
Molecular Weight:330.518
Hs Code.:
NSC Number:186063
UNII:PP2MSY26XX
DSSTox Substance ID:DTXSID40146133
Nikkaji Number:J13.569K
Wikidata:Q83010875
Pharos Ligand ID:RCCF44PYHQYW
ChEMBL ID:CHEMBL53206
Mol file:1039-59-4.mol

Synonyms:Thiomethylpromazine;1039-59-4;TZ 11;Phenothiazine, 10-(3-dimethylaminopropyl)-2-methylthio-;NSC186063;NSC 186063;NSC-186063;BRN 1085742;10-(3-Dimethylaminopropyl)-2-methylthiophenothiazine;Phenothiazine, 10-[3-(dimethylamino)propyl]-2-(methylthio)-;10-[3-(Dimethylamino)propyl]-2-(methylthio)phenothiazine;PP2MSY26XX;NCIStruc1_001990;NCIStruc2_001600;CHEMBL53206;SCHEMBL142864;DTXSID40146133;TZ-11;10H-Phenothiazine-10-propanamine,N,N-dimethyl-2-(methylthio)-;CCG-37144;NCGC00014528;NCI186063;NCGC00014528-02;NCGC00097632-01;C(CCN(C)C)N1c2ccccc2Sc3ccc(SC)cc13;NCI60_001546;LS-105497;WLN: T C666 BN ISJ B3N1&1 ES1;N,N-Dimethyl-2-(methylthio)-10H-phenothiazine-10-propanamine;10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(methylthio)-;N,N-dimethyl-3-(2-(methylthio)-10H-phenothiazin-10-yl)-1-propanamine

Suppliers and Price of Thiomethylpromazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of Thiomethylpromazine

Chemical Property:

Vapor Pressure:3.55E-09mmHg at 25°C
Boiling Point:474.6°C at 760 mmHg
Flash Point:240.9°C
Density:1.22g/cm³
XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:330.12244106
Heavy Atom Count:22
Complexity:350

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)SC

Technology Process of Thiomethylpromazine

There total 4 articles about Thiomethylpromazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.3%

: 506-59-2
N,N-dimethylammonium chloride

: 40256-12-0
10-(3-chloropropyl)-2-(methylthio)-10H-phenothiazine

: 1039-59-4
10-(3-Dimethylamino-propyl)-3-methylmercapto-phenothiazin

Guidance literature:: With triethylamine; In acetonitrile; at 80 ℃;

Reference yield:

: 7643-08-5
2-(methylthio)-10H-phenothiazine

: 1039-59-4
10-(3-Dimethylamino-propyl)-3-methylmercapto-phenothiazin

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium hydride / tetrahydrofuran; mineral oil / 65 °C / Inert atmosphere

2: triethylamine / acetonitrile / 80 °C

With sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; acetonitrile; mineral oil;