2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

Base Information

Chemical Name:2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester
CAS No.:410093-07-1
Molecular Formula:C₂₈H₃₅Cl₃N₆O₆
Molecular Weight:657.981
Hs Code.:

Synonyms:2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

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Chemical Property of 2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

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Technology Process of 2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

There total 1 articles about 2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 545-06-2
trichloroacetonitrile

: 159858-07-8
N-Cbz-Val-Cit-4-aminobenzyl alcohol

: 410093-07-1
2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 16h;
DOI:10.1021/jo016187+

Reference yield:

: 126188-15-6
N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]acetamide

: 410093-07-1
2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

: 159858-07-8
N-Cbz-Val-Cit-4-aminobenzyl alcohol

: 410093-08-2
((S)-1-{(S)-1-[4-((1S,2R)-2-Acetylamino-1-phenyl-propoxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at 0 ℃;
DOI:10.1021/jo016187+

Reference yield:

: 410093-07-1
2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

: 410093-06-0
((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoromethanesulfonic acid / CH₂Cl₂ / 0 °C

2: DIAD; triphenylphosphine / dimethylformamide; toluene / 0 °C

With trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jo016187+