((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

Base Information

Chemical Name:((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester
CAS No.:410093-06-0
Molecular Formula:C₃₆H₄₁N₅O₆
Molecular Weight:639.751
Hs Code.:

Synonyms:((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

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Chemical Property of ((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

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Technology Process of ((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

There total 2 articles about ((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90-15-3
α-naphthol

: 159858-07-8
N-Cbz-Val-Cit-4-aminobenzyl alcohol

: 410093-06-0
((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; toluene; at 0 ℃;
DOI:10.1021/jo016187+

Reference yield:

: 410093-07-1
2,2,2-Trichloro-acetimidic acid 4-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-5-ureido-pentanoylamino]-benzyl ester

: 410093-06-0
((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoromethanesulfonic acid / CH₂Cl₂ / 0 °C

2: DIAD; triphenylphosphine / dimethylformamide; toluene / 0 °C

With trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jo016187+

Reference yield:

: 410093-06-0
((S)-2-Methyl-1-{(S)-1-[4-(naphthalen-1-yloxymethyl)-phenylcarbamoyl]-4-ureido-butylcarbamoyl}-propyl)-carbamic acid benzyl ester

: 90-15-3
α-naphthol

: 159858-06-7
N-[(Benzyloxy)carbonyl]-L-valyl-N₅-carbamoyl-L-ornithine

Guidance literature:: With ethylenediaminetetraacetic acid; acetate buffer; bovine spleen cathepsin B; In water; at 37 ℃; pH=5.1; Enzyme kinetics;
DOI:10.1021/jo016187+