2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine

Base Information

• Chemical Name: 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine
• CAS No.: 85363-69-5
• Molecular Formula: C₄₆H₇₂N₉O₁₄PSi₃
• Molecular Weight: 1090.36

Synonyms:2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine

Chemical Property of 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine

Chemical Property:

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Technology Process of 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine

There total 16 articles about 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2'-O-(tert-butyl)dimethylsilyl-5'-(o-monomethoxytrityl)inosinyl<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine → 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine (85363-69-5)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; chloroform; for 0.5h; Ambient temperature;

Reference yield: 88.0%

C66H88N9O15PSi3 (85363-68-4) → 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine (85363-69-5)

Guidance literature:

DOI:10.1016/S0040-4039(00)85714-7

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 2'-O-(tert-butyl)dimethylsilylinosinyl-<2'-P-(2-(p-nitrophenyl)ethyl)><*>5'>-2,3'-bis-O-(tert-butyl)dimethylsilylinosine (85363-69-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 40 percent / imidazole / pyridine

2: 1.) pyridine

3: oximate

4: 79 percent / quinoline-8-sulfonyl chloride, 3-nitro-1,2,4-triazole / pyridine / 16 h / Ambient temperature

5: 88 percent

With 1H-imidazole; quinoline-8-sulfonyl chloride; oximate; 3-nitro-1,2,4-triazole; In pyridine;

DOI:10.1016/S0040-4039(00)85714-7

upstream raw materials:

C₆₆H₈₈N₉O₁₅PSi₃

2-(4-nitrophenyl)ethanol

5'-O-(4-methoxytrityl)inosine

9-{(2R,3R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Downstream raw materials:

C₉₀H₁₂₀N₁₄O₂₄P₂Si₄

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