(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

Base Information

Chemical Name:(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate
CAS No.:866603-17-0
Molecular Formula:C₄₇H₃₄F₂O₉
Molecular Weight:780.778
Hs Code.:

Synonyms:(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

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Chemical Property of (+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

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Technology Process of (+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

There total 7 articles about (+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 866603-16-9
(+)-7-hydroxy-2-naphthyl (R)-2-(4-hydroxyphenyloxy)propionate

: 152552-64-2
4-(benzyloxy)-3-fluorobenzoic acid

: 866603-17-0
(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/b419479a

Reference yield:

: 79130-11-3
(R)-(+)-2-[4-(benzyloxy)phenyloxy]propionic acid

: 866603-17-0
(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 89 percent / H₂ / Pd/C / dioxane / 50 °C

3: 68 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane;
DOI:10.1039/b419479a

Reference yield:

: 96025-52-4
(R)-2-(4-Benzyloxy-phenoxy)-propionic acid ethyl ester

: 866603-17-0
(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. KOH / ethanol

2: 71 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

3: 89 percent / H₂ / Pd/C / dioxane / 50 °C

4: 68 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; potassium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1039/b419479a