(+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate

Base Information

• Chemical Name: (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate
• CAS No.: 866603-18-1
• Molecular Formula: C₃₃H₂₂F₂O₉
• Molecular Weight: 600.529
• Mol file: 866603-18-1.mol

Synonyms:(+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate

Chemical Property of (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate

There total 8 articles about (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate (866603-17-0) → (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate (866603-18-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; at 50 ℃;

DOI:10.1039/b419479a

Reference yield:

(R)-(+)-2-[4-(benzyloxy)phenyloxy]propionic acid (79130-11-3) → (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate (866603-18-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 89 percent / H₂ / Pd/C / dioxane / 50 °C

3: 68 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

4: 85 percent / H₂ / Pd/C / dioxane / 50 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane;

DOI:10.1039/b419479a

Reference yield:

(R)-2-(4-Benzyloxy-phenoxy)-propionic acid ethyl ester (96025-52-4) → (+)-7-(3-fluoro-4-hydroxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-hydroxybenzoyloxy)phenyloxy]propionate (866603-18-1)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. KOH / ethanol

2: 71 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

3: 89 percent / H₂ / Pd/C / dioxane / 50 °C

4: 68 percent / N,N'-dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

5: 85 percent / H₂ / Pd/C / dioxane / 50 °C

With dmap; potassium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1039/b419479a

upstream raw materials:

(+)-7-(3-fluoro-4-benzyloxybenzoyloxy)-2-naphthyl (R)-2-[4-(3-fluoro-4-benzyloxybenzoyloxy)phenyloxy]propionate

(R)-(+)-2-[4-(benzyloxy)phenyloxy]propionic acid

(R)-2-(4-Benzyloxy-phenoxy)-propionic acid ethyl ester

(+)-7-hydroxy-2-naphthyl (R)-2-(4-hydroxyphenyloxy)propionate