1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

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Chemical Name:1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate
CAS No.:913622-40-9
Molecular Formula:C₁₈H₁₈INO₈
Molecular Weight:503.247
Hs Code.:

Synonyms:1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

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Chemical Property of 1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

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Technology Process of 1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

There total 9 articles about 1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 913622-38-5
1-(3-formamido-6-methoxy-2,5-bis(methoxymethoxy)phenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

: 913622-40-9
1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In dichloromethane; acetonitrile; at 25 ℃; for 0.25h;
DOI:10.1021/jo061054f

Reference yield:

: 854261-03-3
1-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propan-2-ol

: 913622-40-9
1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / DMAP; DCC / dimethylformamide; tetrahydrofuran / 12 h / 50 °C

2: 63 percent / SnCl₂*H₂O; NaBH₄ / ethanol / 0.33 h / Heating

3: 76 percent / CH₂Cl₂ / 12 h / 30 °C

4: 83 percent / NaI; Me₃SiCl / CH₂Cl₂; acetonitrile / 0.25 h / 25 °C

With dmap; sodium tetrahydroborate; chloro-trimethyl-silane; dicyclohexyl-carbodiimide; sodium iodide; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo061054f

Reference yield:

: 854261-02-2
1-(2-methoxy-3,6-bis(methoxymethoxy)phenyl)propan-2-ol

: 913622-40-9
1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NH₄NO₃; (CF₃CO)2O / acetonitrile / 0.25 h / 20 °C

1.2: LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

2.1: 52 percent / DMAP; DCC / dimethylformamide; tetrahydrofuran / 12 h / 50 °C

3.1: 63 percent / SnCl₂*H₂O; NaBH₄ / ethanol / 0.33 h / Heating

4.1: 76 percent / CH₂Cl₂ / 12 h / 30 °C

5.1: 83 percent / NaI; Me₃SiCl / CH₂Cl₂; acetonitrile / 0.25 h / 25 °C

With ammonium nitrate; dmap; sodium tetrahydroborate; chloro-trimethyl-silane; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo061054f