tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

Base Information

Chemical Name:tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate
CAS No.:1402936-91-7
Molecular Formula:C₁₇H₂₂ClNO₂
Molecular Weight:307.82
Hs Code.:

Synonyms:tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

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Chemical Property of tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

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Technology Process of tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

There total 3 articles about tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

: 1402936-89-3
tert-butyl (2E)-3-cyclobutylacrylate

: 60811-17-8
5-bromo-2-chloroaniline

: 1402936-91-7
tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

: 1402936-90-6
tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylacrylate

Guidance literature:: With palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 150 ℃; for 4h; Inert atmosphere;

Reference yield:

: 4415-82-1
cyclobutanemethanol

: 1402936-91-7
tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 - -50 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: -10 - 20 °C

3.1: palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

With oxalyl dichloride; palladium diacetate; sodium hydride; dimethyl sulfoxide; tris-(o-tolyl)phosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2987-17-9
cyclobutylaldehyde

: 1402936-91-7
tert-butyl 3-(3-amino-4-chlorophenyl)-3-cyclobutylidenepropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: -10 - 20 °C

2.1: palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

With palladium diacetate; sodium hydride; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;