1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

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Chemical Name:1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione
CAS No.:1333514-50-3
Molecular Formula:C₂₇H₂₉BrN₄O₃S
Molecular Weight:569.522
Hs Code.:

Synonyms:1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

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Chemical Property of 1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

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Technology Process of 1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

There total 4 articles about 1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1333514-56-9
1-(6-bromohexyl)-3-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)indolin-2-one

: 68-11-1
mercaptoacetic acid

: 1333514-50-3
1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

Guidance literature:: In toluene; for 9h; Reflux;
DOI:10.1016/j.bmcl.2011.06.121

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 1333514-50-3
1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / -10 °C / Inert atmosphere

1.2: -10 - 20 °C / Inert atmosphere

2.1: ethanol / 2 h / 20 °C

3.1: toluene / 9 h / Reflux

With sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.06.121

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1333514-50-3
1-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)spiro[indoline-3,2-thiazolidine]-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / -10 °C / Inert atmosphere

1.2: -10 - 20 °C / Inert atmosphere

2.1: ethanol / 2 h / 20 °C

3.1: toluene / 9 h / Reflux

With sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.06.121