ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

Base Information

Chemical Name:ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate
CAS No.:58859-48-6
Molecular Formula:C₁₅H₂₀F₃N₃O₂
Molecular Weight:331.338
Hs Code.:

Synonyms:ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

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Chemical Property of ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

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Technology Process of ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

There total 4 articles about ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 58859-47-5
4-(2-nitro-4-trifluoromethyl-anilino)-piperidine-1-carboxylic acid ethyl ester

: 58859-48-6
ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; ethanol; for 1h; Ambient temperature;
DOI:10.1021/jm00388a012

Reference yield:

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 58859-48-6
ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃, KI / various solvent(s) / 28 h / 160 °C

2: 83 percent / H₂ / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature

With hydrogen; sodium carbonate; potassium iodide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00388a012

Reference yield:

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 58859-48-6
ethyl 4-[2-amino-4-(trifluoromethyl)phenylamino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃, KI / various solvent(s) / 28 h / 160 °C

2: 83 percent / H₂ / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature

With hydrogen; sodium carbonate; potassium iodide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00388a012