Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate

Base Information

Chemical Name:Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate
CAS No.:58859-47-5
Molecular Formula:C₁₅H₁₈F₃N₃O₄
Molecular Weight:361.321
Hs Code.:
DSSTox Substance ID:DTXSID001145512

Synonyms:SCHEMBL11845003;DTXSID001145512;Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate;58859-47-5

Suppliers and Price of Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:361.12494055
Heavy Atom Count:25
Complexity:476

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)N1CCC(CC1)NC2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]

Technology Process of Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate

There total 3 articles about Ethyl 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 58859-47-5
4-(2-nitro-4-trifluoromethyl-anilino)-piperidine-1-carboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; potassium iodide; In various solvent(s); at 160 ℃; for 28h;
DOI:10.1021/jm00388a012

Reference yield:

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 58859-47-5
4-(2-nitro-4-trifluoromethyl-anilino)-piperidine-1-carboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; potassium iodide; In cyclohexanol; at 180 ℃; for 0.166667h; microwave irradiation;
DOI:10.1016/j.bmcl.2006.07.044