(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Chemical Name:(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one
CAS No.:131652-97-6
Molecular Formula:C₃₀H₃₃NO₅
Molecular Weight:487.596
Hs Code.:

Synonyms:(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Chemical Property of (3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Technology Process of (3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

There total 6 articles about (3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 131652-96-5
1-Benzyl-aziridine-2-carboxylic acid (R)-1-benzyloxymethyl-3-(3,4-dimethoxy-phenyl)-but-3-enyl ester

: 131652-97-6
(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: In xylene; at 250 ℃; for 0.333333h; sealed tube;
DOI:10.1246/cl.1990.1239

Reference yield:

: 131652-78-3,131723-78-9
(R)-5-Benzyloxy-2-(3,4-dimethoxy-phenyl)-pentane-1,4-diol

: 131652-97-6
(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / n-Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

3: CH₂Cl₂ / 5 h / Ambient temperature

4: 100 percent / 30percent H₂O₂ / CH₂Cl₂ / 9 h / 0 deg C to r.t.

5: 85 percent / xylene / 0.33 h / 250 °C / sealed tube

With tributylphosphine; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239

Reference yield:

: 81309-80-0,81309-81-1
(R)-5-Benzyloxymethyl-3-(3,4-dimethoxy-phenyl)-dihydro-furan-2-one

: 131652-97-6
(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2: 94 percent / n-Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

4: CH₂Cl₂ / 5 h / Ambient temperature

5: 100 percent / 30percent H₂O₂ / CH₂Cl₂ / 9 h / 0 deg C to r.t.

6: 85 percent / xylene / 0.33 h / 250 °C / sealed tube

With lithium aluminium tetrahydride; tributylphosphine; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239