(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester
CAS No.:131669-26-6
Molecular Formula:C₃₁H₃₃NO₇
Molecular Weight:531.606
Hs Code.:

Synonyms:(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

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Chemical Property of (3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

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Technology Process of (3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

There total 8 articles about (3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 131652-98-7
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

: 501-53-1,94274-21-2
benzyl chloroformate

: 131669-26-6
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;
DOI:10.1246/cl.1990.1239

Reference yield:

: 131652-78-3,131723-78-9
(R)-5-Benzyloxy-2-(3,4-dimethoxy-phenyl)-pentane-1,4-diol

: 131669-26-6
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / n-Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

3: CH₂Cl₂ / 5 h / Ambient temperature

4: 100 percent / 30percent H₂O₂ / CH₂Cl₂ / 9 h / 0 deg C to r.t.

5: 85 percent / xylene / 0.33 h / 250 °C / sealed tube

6: 88 percent / H₂ / 20percent Pd(OH)2-C / methanol / 8 h / Ambient temperature

7: 85 percent / Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

With tributylphosphine; hydrogen; dihydrogen peroxide; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239

Reference yield:

: 81309-80-0,81309-81-1
(R)-5-Benzyloxymethyl-3-(3,4-dimethoxy-phenyl)-dihydro-furan-2-one

: 131669-26-6
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-7-oxo-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2: 94 percent / n-Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

4: CH₂Cl₂ / 5 h / Ambient temperature

5: 100 percent / 30percent H₂O₂ / CH₂Cl₂ / 9 h / 0 deg C to r.t.

6: 85 percent / xylene / 0.33 h / 250 °C / sealed tube

7: 88 percent / H₂ / 20percent Pd(OH)2-C / methanol / 8 h / Ambient temperature

8: 85 percent / Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

With lithium aluminium tetrahydride; tributylphosphine; hydrogen; dihydrogen peroxide; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239