4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

Base Information

Chemical Name:4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile
CAS No.:1416209-43-2
Molecular Formula:C₂₃H₂₀N₆O₃S
Molecular Weight:460.516
Hs Code.:

Synonyms:4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

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Chemical Property of 4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

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Technology Process of 4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

There total 4 articles about 4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1170005-16-9
C₁₅H₁₃ClN₄O₃

: 54585-47-6
4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

: 1416209-43-2
4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

Guidance literature:: With potassium hydroxide; In water; N,N-dimethyl-formamide; at 15 ℃;
DOI:10.1007/s10593-012-1149-1

Reference yield:

: 27038-81-9
8-(hydroxymethyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione

: 1416209-43-2
4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / Heating

1.2: 2 h / Reflux

2.1: thionyl chloride / 6 h / Reflux

3.1: potassium hydroxide / water; N,N-dimethyl-formamide / 15 °C

With thionyl chloride; potassium hydroxide; sodium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1007/s10593-012-1149-1

Reference yield:

: 953079-61-3
C₁₅H₁₄N₄O₄

: 1416209-43-2
4,6-dimethyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}thio)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 6 h / Reflux

2: potassium hydroxide / water; N,N-dimethyl-formamide / 15 °C

With thionyl chloride; potassium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1007/s10593-012-1149-1