methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

Base Information

Chemical Name:methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate
CAS No.:1343468-70-1
Molecular Formula:C₁₅H₁₄N₂O₄
Molecular Weight:286.287
Hs Code.:

Synonyms:methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

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Chemical Property of methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

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Technology Process of methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

There total 2 articles about methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1343468-59-6
methyl 3-benzylamino-5-oxo-2,5-dihydrofuran-2-carboxylate

: 590-17-0
cyanomethyl bromide

: 1343468-70-1
methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

Guidance literature:: methyl 3-benzylamino-5-oxo-2,5-dihydrofuran-2-carboxylate; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h;

cyanomethyl bromide; In tetrahydrofuran; at 0 ℃; for 2h; regioselective reaction;
DOI:10.1055/s-0030-1260132

Reference yield:

: 103930-94-5
dimethyl 3-(benzylamino)pent-2-enedioate

: 1343468-70-1
methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / ethyl acetate / 24 h / 20 °C

1.2: 0.08 h

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2 h / 0 °C

With N-Bromosuccinimide; sodium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;
DOI:10.1055/s-0030-1260132

Reference yield: 22.0%

: 1343468-70-1
methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate

: 1343468-95-0
(3-benzylamino-5-oxo-2,5-dihydrofuran-2-yl)acetonitrile

Guidance literature:: methyl 3-benzylamino-2-cyanomethyl-5-oxo-2,5-dihydrofuran-2-carboxylate; With sodium hydroxide; In tetrahydrofuran; water; for 0.5h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; Reflux;
DOI:10.1055/s-0030-1260132