Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

Base Information

Chemical Name:Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate
CAS No.:1246246-78-5
Molecular Formula:C₂₀H₂₅N₃O₄
Molecular Weight:371.436
Hs Code.:

Synonyms:Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

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Chemical Property of Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

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Technology Process of Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

There total 5 articles about Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1246246-77-4
6-[(3-{[(Benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylic acid

: 1246246-78-5
Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

Guidance literature:: 6-[(3-{[(Benzyloxy)carbonyl](methyl)amino}propyl)(methyl)carbam oyl]pyridine-3-carboxylic acid; With borane-THF; In tetrahydrofuran; at 20 ℃; for 0.75h; Cooling with ice;

With methanol; In tetrahydrofuran; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1246246-78-5
Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 20 °C / Cooling with ice

1.3: 2 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / methanol / 10 h / 50 °C

2.2: pH 3

3.1: borane-THF / tetrahydrofuran / 0.75 h / 20 °C / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

With borane-THF; water; pivaloyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 111-33-1
1,3-bis(methylamino)propane

: 1246246-78-5
Benzyl {3-[{[5-(hydroxymethyl)pyridin-2-yl]carbonyl}(methyl)amino]propyl}methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 20 °C / Cooling with ice

1.3: 2 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / methanol / 10 h / 50 °C

2.2: pH 3

3.1: borane-THF / tetrahydrofuran / 0.75 h / 20 °C / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

With borane-THF; water; pivaloyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;