trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

Base Information

Chemical Name:trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid
CAS No.:695187-74-7
Molecular Formula:C₁₉H₁₅NO₅
Molecular Weight:337.332
Hs Code.:

Synonyms:trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

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Chemical Property of trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

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Technology Process of trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

There total 4 articles about trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 695187-72-5
trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid t-butyl ester

: 695187-74-7
trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 61873-93-6
methyl (4-hydroxy-3-nitrophenyl)acetate

: 695187-74-7
trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂ / Pd/C / ethyl acetate

2: dioxane / 210 °C / microwave irradiation

3: Pd(OAc)2; (o-Tol)3P; Et₃N / dimethylformamide / 150 °C / microwave irradiation

4: TFA / CH₂Cl₂

With palladium diacetate; hydrogen; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3: Heck reaction;
DOI:10.1016/j.bmcl.2005.03.014

Reference yield:

: 695187-70-3
2-(4-bromophenyl)benzoxazol-5-ylacetic acid methyl ester

: 695187-74-7
trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(OAc)2; (o-Tol)3P; Et₃N / dimethylformamide / 150 °C / microwave irradiation

2: TFA / CH₂Cl₂

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/j.bmcl.2005.03.014