61873-93-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl (4-Hydroxy-3-nitrophenyl)acetate is used as a reagent in the synthesis of various organic compounds for pharmaceutical applications. Its ability to undergo nucleophilic substitution reactions allows for the creation of a wide range of drug molecules, contributing to the development of new medications and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, Methyl (4-Hydroxy-3-nitrophenyl)acetate serves as a versatile intermediate. Its reactivity in nucleophilic substitution reactions enables the synthesis of a variety of organic compounds, which can be further utilized in different chemical processes and applications.
Used in Fine Chemicals Production:
Methyl (4-Hydroxy-3-nitrophenyl)acetate is also used as an intermediate in the production of fine chemicals. Its unique chemical properties and reactivity make it a valuable component in the synthesis of specialty chemicals used in various industries, such as fragrances, dyes, and other high-value products.

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 10463-20-4 4-hydroxy-3-nitrophenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 34837-88-2 methyl 2-(4-methoxy-3-nitrophenyl)acetate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 156-38-7 4-hydroxyphenylacetate 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 

Downstream Products

• 78587-72-1 methyl (3-amino-4-hydroxyphenyl)acetate 
• 185802-57-7 [4-(3-Bromo-propoxy)-3-nitro-phenyl]-acetic acid methyl ester 
• 695187-70-3 2-(4-bromophenyl)benzoxazol-5-ylacetic acid methyl ester 
• 695187-49-6 methyl 2-(2-(4-aminophenyl)benzo[d]oxazol-5-yl)acetate 
• 695187-48-5 methyl 2-(4-nitrophenyl)benzoxazole-5-acetate 
• 695187-97-4 2-(2-fluoro-4-bromophenyl)benzoxazol-5-ylacetic acid methyl ester 
• 695186-49-3 2-[(2-chloro-4-amino)phenyl]-5-benzoxazoleacetic acid methyl ester 
• 695186-53-9 methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate 
• 695186-54-0 methyl [2-(3-fluoro-4-nitrophenyl)benzooxazol-5-yl] acetate 
• 695186-48-2 2-[(2-chloro-4-nitro)phenyl]-5-benzoxazoleacetic acid methyl ester 
• 695187-47-4 4-hydroxy-3-(4-nitrobenzoylamino)phenylacetic acid methyl ester 
• 695187-74-7 trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid 
• 695187-44-1 3-[[(2-chloro-4-nitro)benzoyl]amino]-4-hydroxy-phenylacetic acid methyl ester 
• 695186-52-8 methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate 

Relevant academic research and scientific papers

SECONDARY METABOLITES OF Pyricularia oryzae. I. o-NITROPHENOL DERIVATIVES

o-Nitrophenol derivatives have been isolated from the culture liquid of the deuteromycete Pyricularia oryzae Cav.: 4-hydroxy-3-nitrophenylacetic acid, 4-hydroxy-3-nitrobenzyl alcohol, 1- and 2-(4-hydroxy-3-nitrophenyl)ethanols, N-(4-hydroxy-3-nitrophenylethyl)acetamide, and pyriculamide.This is the first time that any of these compounds has been isolated from natural sources.The o-nitrophenols obtained possess moderate growth-inhibiting activity in relation to rice shoots.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).

Synthetic route to a benzooxazole derivative with heparanase inhibitory activity

The synthesis of a benzooxazol-5-yl acetic acid derivative (9) with strong heparanase and angiogenesis inhibitory activity, and thus possible commercial interest, is described in detail. Copyright Taylor & Francis Group, LLC.

Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions

Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.

Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitor

Using a furanylthiazole acetic acid as a starting point, a novel series of benzoxazol-5-yl acetic acid derivatives have been identified as heparanase inhibitors. Several compounds possess an IC50 of ～200 nM against heparanase, for example, tran

PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES

Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.

Isothiazole derivatives and their use as pesticides

A compound of formula (I), where A is optionally substituted alkylene, alkenylene, alkynylene, cycloalkylene, alkylenoxy, oxy(C1-6)alkylene, alkylenethio, thio(C1-6)alkylene, C1-6alkylenamino, amino(C1-6)alkylene, [C1-6alkyleneoxy(C1-6)alkylene], [C1-6alkylenethio(c1-6)alkylene], [1-6alkylenesulfinyl(c1-6)alkylene], [c1-6alkylenesulfonyl(C1-6)alkylenc] or [C1-6alkyleneamino(C1-6)alkylene]; provided that A is not CH2 or CH2O; B is N, N-oxide or CR8; Y is O, S or NR9; Z is O, S or NR10; and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 are specified radicals; compositions containing them; processes for making them; and their use as insecticides or fungicides.