methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

Base Information

Chemical Name:methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate
CAS No.:603124-61-4
Molecular Formula:C₃₃H₃₉ClN₂O₆
Molecular Weight:595.135
Hs Code.:

methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

Synonyms:methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

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Chemical Property of methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

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Technology Process of methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

There total 1 articles about methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 603124-58-9
methyl 3-amino-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

: 603124-61-4
methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 17h;
DOI:10.1021/jm800222k

Reference yield:

: 603124-61-4
methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

: C₃₂H₃₇ClN₂O₆

Guidance literature:: With methanol; sodium hydroxide; water; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 603124-61-4
methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoate

: 3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-(dimethylamino)benzoic acid dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium hydroxide; water / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; water; In 1,4-dioxane;
DOI:10.1021/jm800222k