4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

Base Information

Chemical Name:4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline
CAS No.:1361968-33-3
Molecular Formula:C₂₇H₂₄ClF₃N₄O
Molecular Weight:512.962
Hs Code.:

Synonyms:4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

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Chemical Property of 4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

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Technology Process of 4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

There total 4 articles about 4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1361968-32-2
2-(6-(bromomethyl)pyridin-3-yl)-4-chloroquinoline

: 340759-27-5
1-(4-(trifluoromethoxy)benzyl)piperazine

: 1361968-33-3
4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

Guidance literature:: With potassium carbonate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm201184h

Reference yield:

: 610768-32-6
2-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

: 1361968-33-3
4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; sodium carbonate / 1,4-dioxane / 100 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 4-methyl-1,2,3-trifluorobenzene / 2 h / 100 °C

3: potassium carbonate / dichloromethane / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tri-tert-butyl phosphine; sodium carbonate; potassium carbonate; In 1,4-dioxane; dichloromethane; 4-methyl-1,2,3-trifluorobenzene;
DOI:10.1021/jm201184h

Reference yield:

: 1361968-31-1
4-chloro-2-(6-methylpyridin-3-yl)quinoline

: 1361968-33-3
4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 4-methyl-1,2,3-trifluorobenzene / 2 h / 100 °C

2: potassium carbonate / dichloromethane / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In dichloromethane; 4-methyl-1,2,3-trifluorobenzene;
DOI:10.1021/jm201184h