5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

Base Information

Chemical Name:5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran
CAS No.:138854-60-1
Molecular Formula:C₃₄H₃₃ClO₄
Molecular Weight:541.087
Hs Code.:

Synonyms:5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

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Chemical Property of 5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

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Technology Process of 5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

There total 10 articles about 5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 18276-82-9
diethyl 2-(p-chlorophenyl)-2-oxo-ethylphosphonate

: 138854-59-8
5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-hydroxy-6-(3-phenoxypropyl)benzofuran

: 138854-60-1
5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 2h;
DOI:10.1021/jm00085a019

Reference yield:

: 100-44-7
benzyl chloride

: 138854-60-1
5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / K₂CO₃ / butan-2-one / 22 h / Heating

2: 1.) BH₃*THF, 2.) a) 30percent aq. H₂O₂, 1 N aq. NaOH, b) NaS / 1.) 0 deg C, 75 min, 2.) a) THF, methanol, 30 min, b) H₂O

3: 68 percent / CBr₄, (C₆H₅)3P / CH₂Cl₂ / 0.75 h

4: 90 percent / NaH / dimethylformamide / 1 h / Ambient temperature

5: 78 percent / acetic acid, water / 18 h / Heating

6: 45 percent / KOt-Bu / dimethylformamide / 2 h / 110 - 120 °C

With sodium hydroxide; borane-THF; carbon tetrabromide; potassium tert-butylate; water; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00085a019

Reference yield:

: 13380-24-0
2,3-dihydro-3,3-dimethyl-2-methoxy-5-benzofuranol

: 138854-60-1
5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / K₂CO₃ / butan-2-one / 4 h / Heating

2: 75 percent / 1,2-dichloro-benzene / 18 h / Heating

3: 90 percent / K₂CO₃ / butan-2-one / 22 h / Heating

4: 1.) BH₃*THF, 2.) a) 30percent aq. H₂O₂, 1 N aq. NaOH, b) NaS / 1.) 0 deg C, 75 min, 2.) a) THF, methanol, 30 min, b) H₂O

5: 68 percent / CBr₄, (C₆H₅)3P / CH₂Cl₂ / 0.75 h

6: 90 percent / NaH / dimethylformamide / 1 h / Ambient temperature

7: 78 percent / acetic acid, water / 18 h / Heating

8: 45 percent / KOt-Bu / dimethylformamide / 2 h / 110 - 120 °C

With sodium hydroxide; borane-THF; carbon tetrabromide; potassium tert-butylate; water; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; butanone;
DOI:10.1021/jm00085a019