18276-82-9

Basic information

• Product Name: Phosphonic acid, [2-(4-chlorophenyl)-2-oxoethyl]-, diethyl ester
• CAS NO: 18276-82-9
• Molecular Formula: C12H16ClO4P
• Molecular Weight: 290.683
• Mol File: 18276-82-9.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [2-(4-chlorophenyl)-2-oxoethyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-(4-chlorophenyl)-2-oxoethyl]-, diethyl ester(18276-82-9)
• EPA Substance Registry System: Phosphonic acid, [2-(4-chlorophenyl)-2-oxoethyl]-, diethyl ester(18276-82-9)

Safety Data

• Hazardous Substances Data: 18276-82-9(Hazardous Substances Data)

Upstream product

• 3095-95-2 diethylphosphonoacetic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 95855-11-1 4'-chloroacetophenone carbomethoxyhydrazone 
• 122-52-1 triethyl phosphite 
• 1615-02-7 p-chlorocinnamic acid 
• 762-04-9 phosphonic acid diethyl ester 
• 7560-44-3 methyl 4-chlorocinnamate 
• 873-73-4 4-n-chlorophenylacetylene 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 683-08-9 Diethyl methylphosphonate 
• 28587-05-5 3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one 
• 6302-55-2 1-(4'-chlorophenyl)-1,3-butanedione 
• 956-02-5 4'-chlorochalcone 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 138854-60-1 5-(benzyloxy)-2-<2-(4-chlorophenyl)-2-oxoethyl>-2,3-dihydro-3,3-dimethyl-6-(3-phenoxypropyl)benzofuran 
• 82102-06-5 diethyl 2-amino-2-(4-chlorophenyl)ethylphosphonate 
• 174832-87-2 [1-(4-Chloro-benzoyl)-but-3-enyl]-phosphonic acid diethyl ester 
• 1451191-62-0 C₁₅H₂₁ClNO₃P 
• 1451191-77-7 C₁₅H₂₁ClNO₃P 
• 1451191-79-9 C₁₅H₂₁ClNO₃P 
• 1245930-64-6 diethyl (1-chloro-2-(4-chlorophenyl)-2-oxoethyl)phosphonate 

Relevant articles and documents

Copper-Catalyzed Microwave-Expedited Oxyphosphorylation of Alkynes with Diethyl Phosphite and t-Butyl Hydroperoxide Synthesis of Densely Functionalized Phosphonylated Indenones

Treatment of alkynes with diethyl phosphite and t-butyl hydroperoxide in the presence of [Cu(MeCN)4]BF4 under microwave irradiation produced the oxyphosphorylation of the triple bond, giving rise to the corresponding β-ketophosphonates in moderate-to-good yields. When the triple bond was conjugated to a carbonyl group bearing an aromatic ring, it led to the cyclization of the resulting ketone intermediate, producing eventually different phosphonylated indenones.

Copper ferrite nanoparticles catalyzed formation of β-Ketophosphonates via oxyphosphorylation of styrenes with H-phosphonates: A DFT study on UV–vis absorption spectra

Typical copper ferrite nanoparticles (CuFe2O4) were used as a catalyst for one-pot synthesis of β-ketophosphonates via the reaction of alkenes with H-phosphonates under conventional heating conditions. The catalyst was prepared by using the coprecipitation method and was analyzed by physiochemical techniques. By using this catalyst system, several types of useful and new β-ketophosphonate products were obtained in very good to excellent yields under optimized reaction conditions in a novel way. Furthermore, the catalyst is recyclable and reusable from the reaction.

Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions

An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.