(R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester

Base Information

• Chemical Name: (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester
• CAS No.: 1233331-01-5
• Molecular Formula: C₁₅H₁₄FNO₂
• Molecular Weight: 259.28
• Mol file: 1233331-01-5.mol

Synonyms:(R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester

Chemical Property of (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester

There total 2 articles about (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (2S)‐2‐[(methylsulfonyl)oxy]‐2‐phenylacetate (60633-83-2) + 4-fluoroaniline (371-40-4) → (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (1233331-01-5)

Guidance literature:

In acetonitrile; at 120 ℃; for 0.0833333h; microwave irradiation;

Reference yield:

Methyl phenyldiazoacetate (22979-35-7) + 4-fluoroaniline (371-40-4) → (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (1233331-01-5) + C15H14FNO2

Guidance literature:

With dirhodium(II) tetrakis(triphenylacetate); (1R,2S)-(+)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol; In dichloromethane; at 23 ℃; for 3h; Overall yield = 90 %; Optical yield = 40 %ee; enantioselective reaction;

DOI:10.1248/cpb.c18-00795

Reference yield: 87.0%

(R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (1233331-01-5) → (R)-(4-fluoro-phenylamino)-phenyl-acetic acid (1233331-04-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 70 ℃; for 12h;

upstream raw materials:

methyl (2S)‐2‐[(methylsulfonyl)oxy]‐2‐phenylacetate

4-fluoroaniline

Methyl phenyldiazoacetate

Downstream raw materials:

(R)-(4-fluoro-phenylamino)-phenyl-acetic acid