2,4,6-trimethylphenyl azide

Base Information

• Chemical Name: 2,4,6-trimethylphenyl azide
• CAS No.: 14213-00-4
• Molecular Formula: C9H11 N3
• Molecular Weight: 161.206
• Mol file: 14213-00-4.mol

Synonyms:Mesitylene,2-azido- (6CI,8CI); 2,4,6-Trimethylphenyl azide;2-Azido-1,3,5-trimethylbenzene; 2-Azidomesitylene; Mesityl azide

Chemical Property of 2,4,6-trimethylphenyl azide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,6-trimethylphenyl azide

There total 8 articles about 2,4,6-trimethylphenyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

mesitylboronic acid (5980-97-2) → 2,4,6-trimethylaniline azide (14213-00-4)

Guidance literature:

With trimethylsilylazide; tetrabutyl ammonium fluoride; copper(l) chloride; In tetrahydrofuran; methanol; for 5h; Reflux; In air;

DOI:10.1002/chem.201000971

Reference yield: 94.0%

2,4,6-trimethylaniline (88-05-1) → 2,4,6-trimethylaniline azide (14213-00-4)

Guidance literature:

2,4,6-trimethylaniline; With hydrogenchloride; water; sodium nitrite; at 0 ℃; for 1.5h; under 760.051 Torr;

With sodium azide; sodium acetate; In water; at 0 - 20 ℃;

DOI:10.1002/asia.201100404

Reference yield: 78.0%

iodomesitylene (4028-63-1) → 2,4,6-trimethylaniline azide (14213-00-4)

Guidance literature:

With sodium azide; copper diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 95 ℃; for 2h;

upstream raw materials:

2,4,6-trimethylaniline

1,3,5-trimethyl-benzene

(2,4,6-trimethylphenyl)(3’-methylphenyl)iodonium triflate

mesitylboronic acid

Downstream raw materials:

5-(2,2,2-trifluoro-1-trifluoromethyl-ethylidene)-2-(2,4,6-trimethyl-phenyl)-2,5-dihydro-[1,2,3,4]thiatriazole

N-mesityl-1,2-disila-1,1,2,2-tetramesitylaziridine

1,4,4,5,5-Pentakis-(2,4,6-trimethyl-phenyl)-4,5-dihydro-1H-[1,2,3,4,5]triazadisilole

2,4,6-trimethylaniline

Refernces

• 1、 Suleman, Suleman,Younus, Hussein A.,Ahmad, Nazir,Khattak, Zafar A.K.,Ullah, Habib,Park, Jihae,Han, Taejun,Yu, Baoyi,Verpoort, Francis. "Triazole based cobalt catalyst for CO2 insertion into epoxide at ambient pressure". . . Retrieved 2020.
• 2、 Jiang, Yuqin,Suo, Huajun,Zhao, Yaru,Li, Xiyong,Sun, Yamin,Li, Xingfeng,Dong, Wenpei,Li, Wei,Zhang, Weiwei,Xu, Guiqing. "DBU-promoted Cu(OAc)2·H2O-catalysed coupling reactions of aryl iodides and sodium azide". . p. 247 - 250. Retrieved 2018.
• 3、 Albrecht, Martin,Keilwerth, Martin,Meyer, Karsten,Pividori, Daniel M.,Stroek, Wowa. "An Iron-Mesoionic Carbene Complex for Catalytic Intramolecular C-H Amination Utilizing Organic Azides". supporting information. p. 20157 - 20165. Retrieved 2021/12/09.
• 4、 Casarrubios, Luis,Díez-González, Silvia,Lachhani, Kushal,Pimpasri, Chaleena,Rzepa, Henry S.,Sebest, Filip,White, Andrew J. P.. "Cycloaddition Reactions of Azides and Electron-Deficient Alkenes in Deep Eutectic Solvents: Pyrazolines, Aziridines and Other Surprises". supporting information. . Retrieved 2020/05/19.