methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate

Base Information

• Chemical Name: methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate
• CAS No.: 1309593-06-3
• Molecular Formula: C₁₉H₂₀F₃NO₃
• Molecular Weight: 367.368
• Mol file: 1309593-06-3.mol

Synonyms:methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate

Chemical Property of methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate

There total 4 articles about methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)but-3-ynoate (1309592-89-9) → methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate (1309593-06-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 24h; under 760.051 Torr; optical yield given as %ee;

DOI:10.1039/c1cc10403a

Reference yield:

methyl 3,3,3-trifluoro-2-(2-methoxyphenylimino)propanoate (1309592-88-8) → methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate (1309593-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethyl zinc(II) / toluene / 1 h / 20 °C / Inert atmosphere

1.2: 2.5 h / 20 °C / Inert atmosphere

1.3: 48 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; dimethyl zinc(II); In methanol; toluene;

DOI:10.1039/c1cc10403a

Reference yield:

2-methoxylphenyl azide (20442-97-1) → methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)butanoate (1309593-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 2 h / Reflux

1.2: Reflux

2.1: dimethyl zinc(II) / toluene / 1 h / 20 °C / Inert atmosphere

2.2: 2.5 h / 20 °C / Inert atmosphere

2.3: 48 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; dimethyl zinc(II); triphenylphosphine; In tetrahydrofuran; methanol; toluene;

DOI:10.1039/c1cc10403a

upstream raw materials:

methyl 3,3,3-trifluoro-2-(2-methoxyphenylimino)propanoate

methyl (R)-2-(2-methoxyphenylamino)-4-phenyl-2-(trifluoromethyl)but-3-ynoate

2-methoxylphenyl azide

2-methoxy-phenylamine

Downstream raw materials:

methyl (R)-2-amino-4-phenyl-2-(trifluoromethyl)butanoate

Refernces