Technology Process of dibenzyl (3aS,4R,5S,7R,7aS)-4-hydroxyhexahydrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-5,7-diyldicarbamate
There total 5 articles about dibenzyl (3aS,4R,5S,7R,7aS)-4-hydroxyhexahydrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-5,7-diyldicarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,3,2',6'-tetrakis(N-benzyloxycarbonyl)-5,6-O-cyclohexylideneneamine;
With
sodium periodate;
In
methanol;
at 0 - 25 ℃;
Inert atmosphere;
Darkness;
With
triethylamine;
In
methanol;
at 40 ℃;
for 13h;
Inert atmosphere;
DOI:10.1002/cbic.201000591
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere
1.2: 1 h / 50 °C
1.3: 20 °C
2.1: sodium periodate / methanol / 0 - 25 °C / Inert atmosphere; Darkness
2.2: 13 h / 40 °C / Inert atmosphere
With
sodium periodate; toluene-4-sulfonic acid;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbic.201000591
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / methanol; water / 6 h / Reflux
2.1: sodium hydrogencarbonate / water / 0.33 h
2.2: 16 h / 0 - 25 °C
3.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere
3.2: 1 h / 50 °C
3.3: 20 °C
4.1: sodium periodate / methanol / 0 - 25 °C / Inert atmosphere; Darkness
4.2: 13 h / 40 °C / Inert atmosphere
With
hydrogenchloride; sodium periodate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cbic.201000591
