Technology Process of dibenzyl (3aS,4R,5S,7R,7aS)-4-hydroxyhexahydrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-5,7-diyldicarbamate
There total 5 articles about dibenzyl (3aS,4R,5S,7R,7aS)-4-hydroxyhexahydrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-5,7-diyldicarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,3,2',6'-tetrakis(N-benzyloxycarbonyl)-5,6-O-cyclohexylideneneamine;
With
sodium periodate;
In
methanol;
at 0 - 25 ℃;
Inert atmosphere;
Darkness;
With
triethylamine;
In
methanol;
at 40 ℃;
for 13h;
Inert atmosphere;
DOI:10.1002/cbic.201000591
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere
1.2: 1 h / 50 °C
1.3: 20 °C
2.1: sodium periodate / methanol / 0 - 25 °C / Inert atmosphere; Darkness
2.2: 13 h / 40 °C / Inert atmosphere
With
sodium periodate; toluene-4-sulfonic acid;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbic.201000591
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / methanol; water / 6 h / Reflux
2.1: sodium hydrogencarbonate / water / 0.33 h
2.2: 16 h / 0 - 25 °C
3.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere
3.2: 1 h / 50 °C
3.3: 20 °C
4.1: sodium periodate / methanol / 0 - 25 °C / Inert atmosphere; Darkness
4.2: 13 h / 40 °C / Inert atmosphere
With
hydrogenchloride; sodium periodate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cbic.201000591