ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

Base Information

Chemical Name:ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate
CAS No.:1458056-21-7
Molecular Formula:C₂₄H₂₂N₄O₄S
Molecular Weight:462.529
Hs Code.:

Synonyms:ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

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Chemical Property of ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

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Technology Process of ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

There total 5 articles about ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: ethyl (4-phenylthiazol-2-yl)glycinate

: 28081-52-9
2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

: 1458056-21-7
ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 49h; Cooling with ice;
DOI:10.1016/j.bmcl.2013.07.067

Reference yield:

: 85-44-9
phthalic anhydride

: 1458056-21-7
ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroform / 5 h / Reflux

2.1: hydrazine hydrate / ethanol / 2 h / 20 - 90 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 0.58 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 49 h / 20 °C / Cooling with ice

With potassium tert-butylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.067

Reference yield:

: 57691-07-3
ethyl [(E)-3-oxo-1,3-dihydroisobenzofuran-1-ylidene]acetate

: 1458056-21-7
ethyl 2-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-phenyl-thiazol-2-yl)acetamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 2 h / 20 - 90 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 0.58 h / 20 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 49 h / 20 °C / Cooling with ice

With potassium tert-butylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.067