Chemical Property of Indolactam V
Chemical Property:
- Appearance/Colour:White to off-white solid.
- Vapor Pressure:1.75E-14mmHg at 25°C
- Melting Point:205.4 - 207.4 °C
- Boiling Point:584 °C at 760 mmHg
- PKA:14.39±0.10(Predicted)
- Flash Point:307 °C
- PSA：68.36000
- Density:1.166 g/cm3
- LogP:2.05570
- Storage Temp.:−20°C
- Solubility.:DMSO: >10mg/mL, clear
- XLogP3:2.3
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:301.17902698
- Heavy Atom Count:22
- Complexity:415
- Purity/Quality:
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98%,99%, *data from raw suppliers
(-)-IndolactamV *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)C1C(=O)NC(CC2=CNC3=C2C(=CC=C3)N1C)CO
- Isomeric SMILES:CC(C)[C@H]1C(=O)N[C@@H](CC2=CNC3=C2C(=CC=C3)N1C)CO
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Description
Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2?Directs differentiation of human and mouse ESCs to pancreatic cells.3?? May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4?Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5
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Uses
(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.
