(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

Base Information

Chemical Name:(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid
CAS No.:174657-20-6
Molecular Formula:C₅₁H₇₂O₈Si
Molecular Weight:841.213
Hs Code.:

(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

Synonyms:(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

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Chemical Property of (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

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Technology Process of (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

There total 33 articles about (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 174657-16-0
(2E,8E,10E)-(4R,5S,6S,12S)-5-(Diethyl-isopropyl-silanyloxy)-12-methoxy-2,4,6,8-tetramethyl-12-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-dodeca-2,8,10-trienal

: (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

: 174657-20-6
(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

Guidance literature:: With potassium hydroxide; In water; at 80 ℃; for 2h;
DOI:10.1021/jo970314d

Reference yield: 64.0%

: 188938-34-3
(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester

: (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

: 174657-20-6
(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; at 80 ℃; for 2h;
DOI:10.1016/0040-4039(95)02351-8

Reference yield:

: 174419-96-6
2,2-Dimethyl-propionic acid (E)-(2R,3S,4S)-3-(diethyl-isopropyl-silanyloxy)-7-iodo-2,4,6-trimethyl-hept-6-enyl ester

: 174657-20-6
(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / <1,1'-bis(diphenylphosphino)ferrocene>palladium(II) chloride / dimethylformamide / 15 h / 50 °C

2: 79 percent / MeLi / diethyl ether / 0.5 h / 25 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 20 min, 2.) to 0 deg C, 40 min.

4: toluene / 4 h / 100 °C

5: 97 percent / DIBAL / toluene / 0.08 h / -78 °C

6: 100 percent / MnO₂ / CH₂Cl₂ / 2 h / 25 °C

7: 64 percent / 1M KOH / H₂O / 2 h / 80 °C

With manganese(IV) oxide; potassium hydroxide; oxalyl dichloride; methyllithium; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo970314d