188938-34-3

Basic information

• Product Name: (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester
• Synonyms: (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester
• CAS NO: 188938-34-3
• Molecular Weight: 855.24
• Mol File: 188938-34-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester(188938-34-3)
• EPA Substance Registry System: (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester(188938-34-3)

Safety Data

• Hazardous Substances Data: 188938-34-3(Hazardous Substances Data)

Upstream product

• 188938-33-2 (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15,17-dihydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 188938-32-1 (2Z,4E,10E,12E)-(6R,7S,8S,14S)-7-(Diethyl-isopropyl-silanyloxy)-2,14-dimethoxy-4,6,8,10-tetramethyl-14-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-tetradeca-2,4,10,12-tetraenoic acid methyl ester 
• 174657-14-8 (2E,8E,10E)-(4R,5S,6S,12S)-5-(Diethyl-isopropyl-silanyloxy)-12-methoxy-2,4,6,8-tetramethyl-12-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-dodeca-2,8,10-trienoic acid ethyl ester 
• 174657-11-5 2,2-Dimethyl-propionic acid (6E,8E)-(2R,3S,4S,10S)-3-(diethyl-isopropyl-silanyloxy)-10-methoxy-2,4,6-trimethyl-10-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-deca-6,8-dienyl ester 
• 174657-16-0 (2E,8E,10E)-(4R,5S,6S,12S)-5-(Diethyl-isopropyl-silanyloxy)-12-methoxy-2,4,6,8-tetramethyl-12-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-dodeca-2,8,10-trienal 
• 174657-15-9 (2E,8E,10E)-(4R,5S,6S,12S)-5-(Diethyl-isopropyl-silanyloxy)-12-methoxy-2,4,6,8-tetramethyl-12-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-dodeca-2,8,10-trien-1-ol 
• 174420-05-4 Toluene-4-sulfonic acid (S)-2-[(4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propyl ester 
• 174657-12-6 (6E,8E)-(2R,3S,4S,10S)-3-(Diethyl-isopropyl-silanyloxy)-10-methoxy-2,4,6-trimethyl-10-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-deca-6,8-dien-1-ol 
• 174657-13-7 (6E,8E)-(2S,3S,4S,10S)-3-(Diethyl-isopropyl-silanyloxy)-10-methoxy-2,4,6-trimethyl-10-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-deca-6,8-dienal 
• 188938-27-4 (4S,5R)-2-(4-Methoxy-phenyl)-5-methyl-4-((S)-1-methyl-but-3-ynyl)-[1,3]dioxane 
• 174420-02-1 1-[(4R,5R)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethanone 
• 174420-04-3 (S)-2-[(4S,5R)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol 
• 188938-26-3 (4R,5R)-4-Isopropenyl-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane 

Downstream Products

• 174657-21-7 (3Z,5E,11E,13E)-(7R,8S,9S,15S,16R)-8-(Diethyl-isopropyl-silanyloxy)-3,15-dimethoxy-16-{(S)-2-[(4-methoxy-phenyl)-diphenyl-methoxy]-1-methyl-ethyl}-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one 
• 88899-55-2 bafilomycin A₁ 
• 174657-20-6 (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid 

Relevant articles and documents

Total synthesis of bafilomycin A1. 2. The assemblage and completion of the synthesis

The total synthesis of the macrolide antibiotic, bafilomycin A1 (1), has been achieved by a convergent route involving aldol condensation between the 16-membered lactonic aldehyde 2 and the ethyl ketone 3, followed by desilylation.