1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

Base Information

Chemical Name:1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea
CAS No.:1436750-59-2
Molecular Formula:C₁₁H₇N₃O₃
Molecular Weight:229.195
Hs Code.:

Synonyms:1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

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Chemical Property of 1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

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Technology Process of 1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

There total 3 articles about 1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₄Cl₃N₃O₄Si

: 1436750-59-2
1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

Guidance literature:: With sodium hydrogencarbonate; In methanol; water; at 18 ℃; for 24h;
DOI:10.1021/ol4007986

Reference yield:

: 1436752-71-4
4-nitro-2-[4-(trimethylsilyl)buta-1,3-diynyl]aniline

: 1436750-59-2
1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 0 - 18 °C / Inert atmosphere

2: sodium hydrogencarbonate / methanol; water / 24 h / 18 °C

With sodium hydrogencarbonate; In methanol; dichloromethane; water;
DOI:10.1021/ol4007986

Reference yield:

: 6293-83-0
2-iodo-4-nitrophenylamine

: 1436750-59-2
1-[4-nitro-2-(buta-1,3-diynyl)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: methyllithium lithium bromide / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 18 °C / Inert atmosphere

1.2: 24 h / 18 °C / Inert atmosphere

2.1: dichloromethane / 2 h / 0 - 18 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / methanol; water / 24 h / 18 °C

With methyllithium lithium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1.2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol4007986