dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

Base Information

Chemical Name:dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate
CAS No.:112113-85-6
Molecular Formula:C₂₃H₂₆N₈O₅
Molecular Weight:494.51
Hs Code.:

dimethyl N-(4-amino-4-deoxy-N<sup>10</sup>methylpteroyl)-D,L-2-amino-4-hexenedioate

Synonyms:dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

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Chemical Property of dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

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Technology Process of dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

There total 3 articles about dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 112113-86-7
dimethyl D,L-2-amino-4-hexanedioate hydrochloride

: 112113-85-6
dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 40h; Ambient temperature;
DOI:10.1021/jm00399a013

Reference yield:

: 1117-71-1
methyl 4-bromocrotonate

: 112113-85-6
dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / LiN(Pr-i)2, HMPA / tetrahydrofuran / 0.5 h / -78 °C

2: 76 percent / aq. HCl / diethyl ether

3: 47 percent / Et₃N, diethyl phosphorocyanidate / dimethylformamide / 40 h / Ambient temperature

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl cyanophosphonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00399a013

Reference yield:

: 112113-87-8
(E)-5-(Benzhydrylidene-amino)-hex-2-enedioic acid dimethyl ester

: 112113-85-6
dimethyl N-(4-amino-4-deoxy-N¹⁰methylpteroyl)-D,L-2-amino-4-hexenedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / aq. HCl / diethyl ether

2: 47 percent / Et₃N, diethyl phosphorocyanidate / dimethylformamide / 40 h / Ambient temperature

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00399a013